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Crisis management during anaesthesia: embolism

¹ Consultant Specialist, Australian Patient Safety Foundation; Visiting Research Fellow, University of Adelaide and Royal Adelaide Hospital, Adelaide, South Australia, Australia
² Department of Medical Biochemistry, School of Medicine, Flinders University, Bedford Park, South Australia, Australia
³ Deputy Director, Department of Paediatric Anaesthesia and Pain Management, Royal Children’s Hospital, Parkville, Victoria, Australia
⁴ Consultant Anaesthetist, Royal Melbourne Hospital, Parkville, Victoria, Australia; Chairman, Victorian Consultative Council on Anaesthetic Mortality and Morbidity

Correspondence to:
Professor W B Runciman
President, Australian Patient Safety Foundation, GPO Box 400, Adelaide, South Australia, 5001, Australia; research{at}apsf.net.au 12 January 2005

	ABSTRACT

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Background: Embolism with gas, thrombus, fat, amniotic fluid, or particulate matter may occur suddenly and unexpectedly during anaesthesia, posing a diagnostic and management problem for the anaesthetist.

Objectives: To examine the role of a previously described core algorithm "COVER ABCD–A SWIFT CHECK" supplemented by a specific sub-algorithm for embolism, in the management of embolism occurring in association with anaesthesia.

Methods: The potential performance of this structured approach for each of the relevant incidents among the first 4000 reported to the Australian Incident Monitoring Study (AIMS) was compared with the actual management as reported by the anaesthetists involved.

Results: Among the first 4000 incidents reported to AIMS, 38 reports of embolism were found. A sudden fall in end-tidal carbon dioxide and oxygen saturation were the cardinal signs of embolism, each occurring in about two thirds of cases, with hypotension and electrocardiographic changes each occurring in about one third of cases.

Conclusion: The potential value of an explicit structured approach to the diagnosis and management of embolism was assessed in the light of AIMS reports. It was considered that, correctly applied, it potentially would have led to earlier recognition of the problem and/or better management in over 40% of cases.

Keywords: embolism; anaesthesia complications; crisis management; gas embolism; air embolism; thrombus; amniotic fluid; monitoring; oximetry; capnography

Embolism may result from intravascular gas, (for example, air, carbon dioxide, oxygen), thrombus, amniotic fluid, fat, bone marrow, aggregated blood products, and a variety of foreign bodies (for example, cannula fragments). Although the healthy pulmonary vascular bed offers a protective filter from moderate systemic venous embolism from these sources, as well as from nitrogen bubbles after dysbaric exposure,¹ it has a finite capacity.² Significant embolism to the right side of the heart and the pulmonary circulation may cause acute heart failure, and even small arterial emboli that access the cerebral and coronary circulations may produce disastrous results. The presence of right-to-left shunting (for example, with a patent foramen ovale and a high right sided pressure) poses the risk of such access with venous embolism.³

Venous or arterial emboli may produce sudden cardiovascular decompensation with rapidly developing falls in end tidal carbon dioxide, haemoglobin saturation, and blood pressure associated with heart rate and rhythm changes.^4,5 Air may be entrained from any venous sinus or large vein (particularly during or immediately after surgery on the brain, head and neck, and spinal cord⁶) or may be forced under high pressure into a vein from poorly primed infusion devices, the re-use of part empty blood infusion bags, and high pressure tissue dissection devices. Carbon dioxide or air may be forced into the circulation via a vascular tear or perforation during minimum access surgery employing insufflation of a body cavity under pressure.⁷ Also embolic air may gain access to the cerebral circulation during problems with cardiopulmonary bypass procedures. In addition to occurring in these well recognised situations, embolism may occur suddenly and unexpectedly under a variety of less usual circumstances (for example, central line disconnection, joint replacement surgery,⁸ IPPV on low compliance lungs⁶). Coupled with the relatively non-specific signs which herald its onset, an anaesthetist may be presented with a difficult diagnostic and management problem.

In 1993, a "core" crisis management algorithm, represented by the mnemonic COVER ABCD–A SWIFT CHECK (the AB precedes COVER for the non-intubated patient), was proposed as the basis for a systematic approach to any crisis during anaesthesia where it is not immediately obvious what should be done, or where actions taken have failed to remedy the situation.⁹ This was validated against the first 2000 incidents reported to the Australian Incident Monitoring Study (AIMS). AIMS is an ongoing study which involves the voluntary, anonymous reporting of any unintended incident which reduced, or could have reduced the safety margin for a patient.¹⁰

It was concluded that if this algorithm had been correctly applied, a functional diagnosis would have been reached in 40–60 seconds in 99% of applicable incidents, and that the learned sequence of actions recommended by the COVER portion would have led to appropriate steps being taken to handle the 60% of problems relevant to this portion of the algorithm.⁹ However, this study also showed that the 40% of problems represented by the remainder of the algorithm, ABCD–A SWIFT CHECK, were not always promptly diagnosed or appropriately managed.^5,9,10 It was decided that it would be useful, for these remaining problems, to develop a set of sub-algorithms in an easy-to-use crisis management manual.¹¹ This study reports on the potential place of the COVER ABCD–A SWIFT CHECK algorithm in the diagnosis and initial management of embolism, provides an outline of a specific crisis management sub-algorithm for embolism during anaesthesia, and provides an indication of the potential value of using this structured approach.

	METHODS

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Of the first 4000 incidents reported to AIMS, those which made reference to embolism were extracted and analysed for relevance, presenting features, causes, diagnosis, management, and outcome. The COVER ABCD–A SWIFT CHECK algorithm, described elsewhere in this set of articles,¹¹ was applied to each relevant report to determine the stages at which the problem might have been diagnosed and to confirm that activating the COVER portion would have led to appropriate initial steps being taken. As embolism is not adequately dealt with by this algorithm, a specific sub-algorithm for embolism was developed (see fig), and its putative effectiveness was tested against the reports. How this was done is described elsewhere in this set of articles.¹¹ The potential value of this structured approach (that is, the application of COVER ABCD–A SWIFT CHECK to the diagnosis and initial management of the problem, followed by the application of the embolism sub-algorithm) was assessed in the light of AIMS reports by comparing its potential effectiveness for each incident with that of the actual management, as recorded in each report.

	RESULTS

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There were 67 reports that contained the word "embolism". Twenty nine of these referred to a past history of embolism (usually pulmonary thromboembolism), or mentioned the diagnosis only to dismiss it. The remaining 38 reports were analysed for this study.

The nature of the embolus was considered to be air in 32 reports, carbon dioxide in four, thrombus in one, and fat in one. The source was the surgical field in 27 cases (71%), a venous catheter in eight cases (21%) (peripheral in six and central in two cases), and a radial arterial catheter, "deep veins" and fat embolism in one case each. The patient’s ASA grade was available in 36 cases: ASA I, seven (five emergency) cases; ASA II, 14 (six emergency) cases, ASA III, 13 (five emergency) cases, and ASA IV, two (no emergency) cases.

The operative procedures which generated the 38 reports are shown in table 1, the clinical feature which first alerted the anaesthetist in table 2 and those features which subsequently also became apparent in table 3. The clinical management is presented in table 4.

When the COVER ABCD–A SWIFT CHECK algorithm was applied to each report, it was considered that the problem would have been detected in all cases at the C1 (circulation) or C2 (colour) stage of COVER or, failing that, at the R1 (review monitors) stage of COVER. If the diagnosis had not been made at the SCAN or CHECK levels of COVER, then it was considered that it would have been made when the A (Air embolism, Air in the pleural cavity, Allergy/Anaphylaxis, and Awareness) of A SWIFT CHECK was considered, particularly in conjunction with the SWIFT CHECK portion of the algorithm (see Discussion). It was considered that the cause would have been detected during the SWIFT CHECK portion of the algorithm, and that the actions recommended by COVER would have constituted appropriate immediate steps for air embolism. It was also considered that carrying out the recommendations of the embolism sub-algorithm outlined in figure 1 would have constituted appropriate management in all cases.

View larger version (53K): [in this window] [in a new window]   Figure 1  Air (and other) embolism.

There was delay in recognition of embolism in 11 cases: four cases presented with and were treated as desaturation for some time before other signs were elicited (in one of these cases ventilation was progressively reduced because of a low end tidal carbon dioxide, before it was realised that ongoing air embolism from the surgical field was causing the changes in both saturation and end tidal carbon dioxide), one presented with and was initially treated as bradycardia, and three cases presented as cardiac arrests. In five of these cases diagnosis was delayed in spite of the fact that several cardinal signs were noted. Diagnosis was delayed in four cases because no oximetry was in use and in three cases because no capnography was in use.

	DISCUSSION

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Embolism must be considered immediately whenever a fall in end tidal carbon dioxide and saturation occur in rapid succession. It should also be considered with hypotension, a change in heart rate or rhythm, a change in configuration of the electrocardiogram waveform, and with any of the clinical signs listed in figure 1 (left hand panel). It was considered that the COVER ABCD–A SWIFT CHECK algorithm would have detected a problem in all cases in this series at the C1 or C2, or failing that, the R1 stages of COVER at the SCAN level, had it been applied in the recommended manner.

However, it was considered that the use of COVER at the SCAN or CHECK level would not necessarily identify embolism as the cause of the problem. When the COVER ABCD algorithm has been completed at the CHECK level, and the cause of the problem is still not evident, the four As of A SWIFT CHECK must be specifically considered. In the "reminder" for the four As, "Be Aware of Air and Allergy", Air serves as a reminder for Air (or other) embolism and for Air in pleura (pneumothorax). The four As each represent about 0.5–1.5% of incident reports, and share the feature that certain clinical signs and/or situations should immediately be searched for when certain combinations of changes are evident on the monitors. Thus, consideration of the four problems represented by the A preceding SWIFT CHECK provides a further primary chance to diagnose air (or other) embolism.

The SWIFT CHECK portion of the algorithm may also play a role in establishing the diagnosis and cause of embolism. In addition to reviewing the monitors, a careful check should be made of the patient, of what the surgeon is doing, and of all intravascular lines and infusions. Embolism should be considered even when only one of the signs or high risk situations, listed in the figure, is present and remains unexplained, although a disconnection or leak in the gas sampling system to the capnograph should be considered when there is a sudden fall in end tidal carbon dioxide with no other sign.

If embolism is thought to have taken place, the COVER algorithm should be invoked in its full EMERGENCY form, including turning off the vaporiser, with the exception that it is not necessary to separate the patient from the anaesthetic machine if the oxygen analyser reads 100% and vapour concentrations fall to zero after turning off the vaporiser. The additional steps that should be taken for the embolism sub-algorithm are listed in the figure under "Emergency Treatment", including the use of Doppler or transoesophageal echocardiography if available.¹² On the available evidence, if these steps and those listed under COVER-EMERGENCY are taken, we consider that appropriate crisis management would have taken place.

In the recovery phase, the patient should undergo a thorough survey of all systems, and should be reviewed each day for 2–3 days. For proven cerebral arterial gas embolism, early hyperbaric oxygen therapy is indicated.^13,14 An intravenous infusion of lignocaine (0.06 mg/kg/min initially) may also be beneficial, especially if hyperbaric oxygen therapy is delayed.¹⁵

Finally, it is important that a full explanation of what happened be given to the patient and the problem clearly documented in the anaesthetic record. If a particular precipitating event was significant, or a particular action was useful in resolving the crisis, this should be clearly explained and documented.

In summary, embolism is a potentially life threatening complication which may occur unexpectedly. Anaesthetists should have a high index of suspicion in known risky situations such as the now commonplace surgical techniques involving body cavity insufflation. Continuous monitoring of end tidal carbon dioxide concentrations and of saturation (both with appropriate alarm settings) should allow the rapid diagnosis of this problem. The algorithm presented in the figure provides an outline for the immediate emergency management, with recommendations for follow up. It was considered that had the structured approach recommended been carried out (that is, the application of COVER ABCD–A SWIFT CHECK for diagnosis, followed by activating the COVER portion of this algorithm and then carrying out recommendations for the embolism sub-algorithm outlined in the figure), it would have led to earlier recognition of the problem and/or better management in 41% of cases.

Key messages Thirty eight embolism incidents associated with anaesthesia were found among the first 4000 reports to the AIMS. The types of emboli were air (32 reports), CO2 (four reports), thrombus (one report), and fat (one report). There were no deaths directly attributable to embolism in this series. The sources of the emboli were the surgical field in 27 cases (71%) (NB liver surgery), a venous catheter in eight cases (21%; peripheral in six cases, central in two cases), and one case each of a radial arterial catheter, deep venous thrombosis, and "fat embolism". Sixteen of the 38 cases involved emergency cases. Three cases presented as cardiac arrests. Doppler monitoring was not used in any of the cases in this series. The commonest of the 10 operative procedures implicated were intravascular line placement and intracranial surgery. Primary detection was most commonly by a fall in ETCO2 (34%), desaturation (26%), and "human" detection (18%). Of the 15 different clinical strategies reported, many used in combination, the most common were "change FIO2 to 1.0", "communicate with the surgeon", "change to manual IPPV", and "control the source of air". There was delay in recognition of embolism in 11 cases, in five of which several cardinal signs were noted. Continuous monitoring with both capnography and oximetry (with alarm settings) should allow rapid diagnosis of embolism in the absence of Doppler monitoring. It was considered that the use of the core algorithm combined with the specific sub-algorithm for embolism would have constituted appropriate management in all cases in this series.

 

	ACKNOWLEDGEMENTS

 
The authors would like to thank all the anaesthetists in Australia and New Zealand who contributed to the 4000 incident reports upon which this and the other 24 papers in the Crisis Management Series are based. The coordinators of the project also thank Liz Brown for preparing the draft of the original Crisis Management Manual; Loretta Smyth for typing; Monika Bullock, RN, for earlier coding and classifying of data; Dr Charles Bradfield for the electronic version of the algorithms; Dr Klee Benveniste for literature research; Drs Klee Benveniste, Michal Kluger, John Williamson, and Andrew Paix for editing and checking manuscripts.

	FOOTNOTES

 
This study was coordinated by the Australian Patient Safety Foundation, GPO Box 400, Adelaide, South Australia, 5001, Australia

	REFERENCES

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				W B Runciman, M T Kluger, R W Morris, A D Paix, L M Watterson, and R K Webb Crisis management during anaesthesia: the development of an anaesthetic crisis management manual Qual. Saf. Health Care, June 1, 2005; 14(3): e1 - e1. [Abstract] [Full Text] [PDF]

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